Tuesday, March 26, 2013

Old mice, young blood: Rejuvenating blood of mice by re-programming stem cells that produce blood

Mar. 25, 2013 ? The blood of young and old people differs. In an article published recently in the scientific journal Blood, a research group at Lund University in Sweden explain how they have succeeded in rejuvenating the blood of mice by reversing, or re-programming, the stem cells that produce blood.

Stem cells form the origin of all the cells in the body and can divide an unlimited number of times. When stem cells divide, one cell remains a stem cell and the other matures into the type of cell needed by the body, for example a blood cell.*

"Our ageing process is a consequence of changes in our stem cells over time," explained Martin Wahlestedt, a doctoral student in stem cell biology at the Faculty of Medicine at Lund University, and principal author of the article.

"Some of the changes are irreversible, for example damage to the stem cells' DNA, and some could be gradual changes, known as epigenetic changes, that are not necessarily irreversible, even if they are maintained through multiple cell divisions. When the stem cells are re-programmed, as we have done, the epigenetic changes are cancelled."**

The discovery that forms the basis for the research group's method was awarded the Nobel Prize in Medicine last year.

The composition of blood is one example of how it ages; blood from a young person contains a certain mix of B- and T-lymphocytes and myeloid cells.***

"In older people, the number of B- and T-lymphocytes falls, while the number of myeloid cells increases," said Martin Wahlestedt.

When an elderly person is affected by leukemia, the cancer often has its origin in the myeloid cells, of which the elderly have more. Being able to 're-start' the blood, as Martin and his colleagues have done in their studies on mice, therefore presents interesting possibilities for future treatment.

"There is a lot of focus on how stem cells could be used in different treatments, but all that they are routinely used for in clinical work today is bone marrow transplants for diseases where the blood and immune systems have to be regenerated," said Martin Wahlestedt, continuing:

"A critical factor that gives an indication of whether the procedure is going to work or not is the age of the bone marrow donor. By reversing the development of the stem cells in the bone marrow, it may be possible to avoid negative age-related changes."

Even if the composition of the blood in old and young mice is remarkably like that in young and elderly people, Martin Wahlestedt stressed that the science is still only at the stage of basic research, far from a functioning treatment. The research group is pleased with the results, because they indicate that it may not primarily be damage to DNA that causes blood to age, but rather the reversible epigenetic changes.

*About stem cells:

There are different types of stem cells. Embryonic stem cells, which can be extracted from an embryo at an early stage, have the capacity to develop into all types of cell. Stem cells are also found in adults, where they have more limited development potential, but can divide in principle an unlimited number of times. For example, blood cell-forming stem cells in bone marrow create all types of blood cell and stem cells in the brain create many different types of brain cell.

**About epigenetics:

Epigenetics is a term that has historically been used to describe the aspects of genetics that cannot be explained by the composition of an individual's DNA alone. For tissue and organs to form, a number of different types of cell must be developed. This happens through the activation and de-activation of different genes. When a cell formed in this manner then divides again, the gene expression can be maintained in the daughter cells. This is referred to as 'epigenetic inheritance'. The epigenetic mechanisms, or which genes are activated or de-activated, can be affected by factors such as age, chemicals, drugs and diet.

*** About the composition of blood:

B- and T-lymphocytes and myeloid cells are all white blood cells. Lymphocytes, as the name suggests, are particularly common in the lymphatic system. T-lymphocytes patrol the body and recognise a specific bacteria or virus. B-lymphocytes 'remember' old infections and can quickly be activated again if required. This memory capacity is the mechanism behind immunity. The myeloid cells belong to the blood system's 'big eaters' -- they neutralise damaged tissue, dead cells, and to a certain extent also bacteria.

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Story Source:

The above story is reprinted from materials provided by Lund University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. M. Wahlestedt, G. L. Norddahl, G. Sten, A. Ugale, M.-A. Micha Frisk, R. Mattsson, T. Deierborg, M. Sigvardsson, D. Bryder. An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state. Blood, 2013; DOI: 10.1182/blood-2012-11-469080

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/YJJ0QkbuMwQ/130325093659.htm

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Bloomberg: Nanny-in-chief or crusader? (CNN)

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Senate shows united support for blocking Iran access to euros

WASHINGTON (Reuters) - The Senate showed strong support over the weekend for blocking Iran's access to euros, as Congress continues to push for additional measures to choke funding to Tehran's nuclear program.

The Senate unanimously passed a non-binding amendment to the budget plan early on Saturday that seeks to stop Iran from using a loophole allowing it use the European Central Bank's interbank payment system to gain access to euros.

The amendment, sponsored by Illinois Republican Mark Kirk and West Virginia Democrat Joe Manchin, is symbolic, as the budget will not become law. It follows a letter signed last month and sent to the European Union by 36 senators, and could indicate the Senate would introduce legislation later on the issue.

Washington and the EU last year hit Iran with sanctions that slashed its crude exports by half. That led to inflation and pushed down the rial, Iran's currency. Still, Iran's government has access to vast foreign currency reserves, including supplies of euros, that senators say helps it stabilize the budget and circumvent the sanctions.

"Closing the euro loophole in our sanctions policy is critical in our efforts to prevent Iran from acquiring a nuclear weapons capability," Kirk said. "The U.S. Senate has spoken and now the European Union needs to act."

The EU office in Washington did not immediately comment.

Iran is enriching uranium to a concentration that countries in the West say can relatively easily be made suitable for nuclear weapons. Tehran says the program is for generating electricity and medical purposes.

There is no indication U.S. and EU sanctions are pressuring Iran's leaders to slow the program. Sellers of oil have found numerous ways around sanctions.

A proponent of sanctions on Iran said closing the euro loophole is a necessary step: Without a rapid plunge in Iran's accessible foreign exchange reserves, Tehran has resources to get beyond the point where the country achieves an undetectable nuclear bomb, said Mark Dubowitz, head of the Foundation for Defense of Democracies.

The amendment argues that the Iranian government maintains bank accounts around the world filled with foreign exchange reserves, the majority of which are held in euros.

(Reporting by Timothy Gardner; editing by Andrew Hay)

Source: http://news.yahoo.com/senate-shows-united-support-blocking-iran-access-euros-164415919--business.html

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Sunday, March 24, 2013

From Hoops to Harry Potter: Behind the Scenes of the Senate's All-Nighter

The Senate?s vote-a-rama began shortly before 4 p.m., as former pre-school teacher Patty Murray warned her senatorial pupils about wandering off the floor.

?You leave at your own peril,? she said, the chairman of the Senate Budget Committee and master of these ceremonies.

Plenty wandered off anyway. The marathon voting session came, after all, on the eve of a two-week congressional recess and in the midst of the second night of March Madness basketball.

Even Sen. Mitch McConnell, the GOP leader who has mercilessly chastised Democrats for failing to put a budget on the floor for four years, admitted to splitting his attention between the floor proceedings and his home-state Western Kentucky Hilltoppers. ?Sen. McConnell cheering on #WKU from the U.S. Capitol tonight in between #budget votes. #GoTopps!? his office tweeted during the game. (They lost 57-64 to No. 1-ranked Kansas.)

Senators? shoulders slumped, tempers flared and Harry Potter even made a cameo in the congressional record as the voting dragged into the early Saturday hours.

As each roll call vote was taken, senators streamed from the sanctuary of their separate cloakrooms to cast votes for nonbinding budget amendments that ranged from the Keystone pipeline (backed by 62 senators, including 17 Democrats) to a carbon tax (overwhelmingly defeated) to instituting stricter sales tax collections on Internet purchases (it, too, passed).

By 6:30 in the evening, the second floor of the Capitol smelled of barbeque. A buffet was dished out in McConnell?s office, as Republican senators traipsed back and forth from the floor holding paper plates piled high with meat, cornbread, baked beans and salad.

For a while, Sen. Elizabeth Warren, D-Mass., decamped to a quiet hallway off the floor, whipping out her laptop to catch up on work. She was sure to return to the floor as the Senate took up a measure to express the chamber?s displeasure with federal subsidies for ?too big to fail? banks. There was no opposition but members wanted a recorded vote anyway.

It passed 99-0 and clapping erupted -- a big Senate no-no -- in the well of the chamber. Sen. Kirsten Gillibrand, D-N.Y., pointed blame at Sen. Claire McCaskill, D-Missouri. ?It was Schumer,? McCaskill pleaded innocently. (Both she and Schumer had clapped.)

Sen. Ron Wyden, D-Oregon, thumbed through an iPad on the floor during one of many recorded tallies, perhaps unaware that one of Senate Republicans? favorite talking points in recent months has been that the iPad didn?t exist the last time Senate Democrats passed a budget.

At least he wasn?t making any noise. The volume on the floor kept steadily growing as Murray asked the chair to restore order. Around 10 p.m., Murray declared, ?I know there is alot of March Madness going on but I?d like to keep calm on the floor.? The chamber quieted briefly before returning to the mood and noise level of a cocktail party, befitting the late Friday night hour.

Even the leaders of the Senate budget warring -- Republican Sen. Jeff Sessions of Alabama and Murray -- stood together and laughed, at times. Just weeks earlier, Sessions had accused Murray of insinuating that he disliked poor people during a budget ?hearing related to welfare and food stamps.

Gillibrand was spotted showing off Friday?s New York Times, which featured a front-page story about the growing clout of women in the Senate. She flipped and pointed her colleagues to the story?s jump page, which just so happened to feature a prominent color photo of her. Meanwhile, Sen. Orrin Hatch, R-Utah, sat in his chair, reading a hardcover book in his newish black-framed hipster glasses.

Around 11 p.m., Senate Majority Leader Harry Reid came to the floor to praise the evening?s progress. ?We?re doing fine,? he said. ?We?re not at carnival stage yet. Let?s proceed and try to reach this with a lot of dignity.?

None of these late-night votes had any chance of making it into law. Instead, this marathon session was all about setting policy precedents and scoring political points ahead of the 2014 mid-term elections, when the Republicans hope to take back the Senate.

Senators loosened further as the clock ticked past midnight. Sen. Tom Harkin, D-Iowa, rose to oppose an amendment that defunded, in some way, a part of the president?s health care law, likening the GOP effort to tossing ?Harry Potter?s invisibility cloak? over the legislation. The amendment, one of multiple attempts to chip away at the health care?law during the vote-a-rama, failed by a voice vote.

Good humor was in shorter-supply around 1:30 a.m., as Republicans continued to demand more votes. ?Reid pulled off his glasses and rubbed his eyes during one exchange between Murray and Sessions. Murray pleaded with Republicans to consider the Senate?s ?elderly? members.

The amendments continued unabated.

By 3 a.m., Reid and Murray demanded that senators, like unruly schoolchildren, stay seated in their desks to speed up the process.

Republicans obliged, happy to be having their say on the floor, no matter the time.

"This," declared McConnell past 4:30 a.m., "is one of the Senate's finest days in recent years."

The world's greatest deliberative body was about to pass a budget without a single vote to spare.

Source: http://news.yahoo.com/hoops-harry-potter-behind-scenes-senates-nighter-110320102--politics.html

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Teen shot dead after sneaking into wrong home following party

Dozens gathered Thursday night to remember Caleb Gordley, a Virginia teen who was shot by a homeowner after he mistakenly snuck into a neighbor's home early Sunday.

"Caleb had a lot of friends, a lot of people who loved him, even more than I ever knew," Caleb's father, Shawn Gordley, told News4's Shomari Stone.

Gordley, of Loudoun County,?was shot after he snuck into the home through a window, setting off the home's alarm.

Earlier Thursday, authorities had said the homeowner had called 911, warned Gordley verbally and fired a warning shot before firing the shots that struck and killed the teen.

Authorities have said they believe Gordley had mistaken the house for his own and was trying to sneak back in after a night of partying. He died at the scene.

The teen - who was a three-sport athlete at Park View High School, Sterling, Virginia, and aspired to be a rapper - was remembered as a good friend and son.

"He was very respectful," Shawn Gordley said. "He respected life, respected everybody he ever met."

The sheriff's office said Thursday that Gordley - who lived two houses away - had been drinking and entered the his neighbor's house about 2:30 a.m. through a rear, unlocked window. The sheriff's office said Gordley did not enter the home with any criminal intent.

The sheriff's department said the gun that the homeowner used, a .40-caliber pistol, appears to be legally owned.

Read more from NBCWashington.com

According to the sheriff's department, the homeowner had come to investigate the alarm when he encountered someone on the stairs leading to the second floor.

The homeowner "gave verbal warnings and discharged the firearm as a warning," according to a statement issued by the sheriff's department Thursday afternoon.

But the teen continued up the stairwell and into a hallway. The homeowner shot at the teen, and struck him once in the left shoulder as he passed the homeowner in the hallway and walked toward an upstairs bedroom that was occupied by other residents of the home. They will not close their investigation until the final medical examiner's report is complete.

The sheriff's office say they are conducting a separate investigation on how Gordley obtained alcohol.

Gordley's parents have said they do not blame the homeowner.

"I want you to know, sir, I forgive you," said Jennea Gordley, Caleb's mother, on Tuesday. "I understand this was an accident. I truly believe everything happens for a reason. My son, he's an angel.?

NBCWashington.com

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/29e54720/l/0Lusnews0Bnbcnews0N0C0Inews0C20A130C0A30C230C174249640Eteen0Eshot0Edead0Eafter0Esneaking0Einto0Ewrong0Ehome0Efollowing0Eparty0Dlite/story01.htm

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How to Build Effective Team for Business ? EBook Free Download

How to Build Effective Team for Business ? EBook Free Download

How to Build Effective Team, Effective Team Building, Build Effective Teams, Building Effective Team, Building an Effective Team, Building Effective Teams and Teamwork, Effective Team Management, Effective Team Building StrategiesA tidal wave of info on building your team. Do you want to create your own team of motivated marketers? Learn how to create your own team of marketers and watch your profits soar!

It?s great to have a successful business of your own where you?re the boss and there is no one to? tell you what to do. You play by your own rules and it?s up to you, what? you want to do.

However, there?s only so much you can do if you are a one man operation. For instance, if you want to create an info product and launch it within a week, you got to create your product, design the graphics, write the sales copy, communicate with your JV or affiliates.

It sounds like an exhausting list of tasks. What if there were people to take care of all the tedious tasks and complete it twice as fast.

Wouldn?t?that be good? It will leave you to focus on other things you are actually good at like writing or networking with people,

It sounds great and all but to find the right people is easier said than done.

Not everyone who works for you are going to do a great job or would they be as dedicated as yourself.

But if you were to find few good people who are as motivated as yourself, you will grow your business rapidly and grow faster than you can imagine.

So how do you find the right people and avoid the mistake of getting the wrong team members who can slow down your progress?

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Source: http://electrapk.com/how-to-build-effective-team-for-business-ebook-free-download/

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Dell Latitude 10 review: a business-friendly Windows tablet with ...

Dell Latitude 10 review: a business-friendly Windows tablet with great battery life

We've been making the grand tour of Windows 8 hybrids running low-powered Atom processors, and our latest stop is Dell's Latitude 10. While some similar systems, such as the ASUS VivoTab Smart and the Lenovo ThinkPad Tablet 2, focus on portable designs and long battery life, the Latitude 10 takes after that group of devices with "Smart" and "Pro" in their name.

Indeed, like the Surface Pro and Samsung ATIV Smart PC Pro, the Latitude 10 flaunts a large variety of corporate-friendly features, such as TPM, a productivity dock, a Wacom-certified stylus and a Bluetooth keyboard. The entry-level configuration will set you back a tolerable $499, but adding on business essentials such as the dock and keyboard could soon have you looking at a price above the $1,000 threshold. Does the Latitude 10 work well enough to warrant the dough -- and satisfy on-the-go professionals? You know where to look if you want to find out.

Look and feel

DNP Dell Latitude 10 review an Atompowered hybrid with great battery life

"Inoffensive" is the word we'd use to describe the Latitude 10's design -- and we imagine that's exactly what many corporate customers will want. Though we have no qualms with the straightforward, black-rectangle aesthetic, we do take issue with the extremely wide bezel surrounding the 1,366 x 768 display. This cheapens the device's feel, and it makes the 10.1-inch panel seem smaller.

"Inoffensive" is the word we'd use to describe the Latitude 10's design -- and we imagine that's exactly what many corporate customers will want.
At 1.45 pounds and 0.4 inch thick with a 30Wh battery, this isn't anywhere near the wispiest 10.1-incher around, but it does feel plenty sturdy in the hand. This is thanks to a reinforced magnesium-alloy frame, and the coating of Gorilla Glass doesn't hurt either. The back sports a soft-touch finish that makes for a comfortable grip -- you shouldn't have to put this tablet's solid build to the test with any accidental drops.

By and large, button and port placement makes perfect sense on the Latitude 10 -- and there is no shortage of connections on board. The physical Windows 8 Start button sits in its typical spot underneath the screen. Oddly, though, the button is slightly recessed rather than raised, and as a result it's a bit tricky to press. We had to apply more pressure than we're used to, and it was especially difficult to register a press when the tablet was angled upright in the bundled dock. The only other feature you'll notice on the front is the 2-megapixel, front-facing camera.

The top edge of the Latitude 10 is home to a full-size SD card slot, the power button and a toggle for auto-rotate. The Enhanced Security model, which we got a chance to play with, includes a smart card reader along the top. The combo headphone / mic jack, USB 2.0 port and mini-HDMI connection sit on the right edge, while you'll find the volume rocker and Kensington lock slot on the left. Finally, the power connector and a micro-USB port line the bottom side. Turn the device over, and you'll find plenty going on. In addition to the 8MP rear shooter with LED flash, the Dell logo and two small sets of speakers, the swappable 30Wh battery sits prominently on the backside, with a slide lock allowing for its removal. (A larger 60Wh battery was included with our review unit -- more on that later.)

Our unit offers 3G connectivity, and the micro-SIM slot is located under the removable power pack. The battery takes up a good half of the surface, and while this interrupts the otherwise clean lines, the promise of longer battery life trumps any superficial design concerns. We had to wiggle both the two- and four-cell batteries loose when switching them out, as the latch system got stuck halfway when we tried to move it.

Etc.

DNP Dell Latitude 10 review an Atompowered hybrid with great battery life

The variety of configuration options for the Latitude 10 verges on confusing. Not only are there Essential, Standard and Enhanced Security models, but there are a slew of optional accessories as well. We checked out a Latitude 10 bundled with the productivity dock, a $100 add-on. This 1.8-pound peripheral adds to an already impressive number of ports, with four USB 2.0 connections, a headphone jack and a full-size HDMI for hooking up an external monitor. There's also a power connector for charging the tablet while it's docked.

It was easy to attach the Latitude 10 to the stand, but it felt rather wobbly; lifting up on the slate detached it from the base -- and that was without applying much pressure. We imagine the dock won't move far from users' desks, though, and it offers a comfortable -- though non-adjustable -- viewing angle for both watching movies and composing emails and documents. Other accessories include a Bluetooth keyboard and mouse combo (ranging from $40 to $86, depending on which of the three bundles options you choose) and a $40 soft-touch case that can act as a stand. Our review unit also came with the $40 Dell KM632 keyboard and mouse package, along with the case.

Speaking of the Bluetooth keyboard and mouse, we had to force ourselves to use the device in tablet mode after enjoying this setup. You'll definitely want a set of hardware keys if you plan to do any real work, and both the chiclets and the mouse were responsive and comfortable for navigating Windows 8. That said, the Bluetooth keyboard is desktop-size, meaning the slate's 10.1-inch screen feels small in comparison. One other nitpick: the top of the mouse is removable, allowing you to insert the two AA batteries, and it comes off far too easily. We had to reattach it on several occasions during our hands-on time. Dell doesn't offer its own keyboard case; rather, it sells the Kensington KeyFolio Expert through its website.

Display, pen input and sound

DNP Dell Latitude 10 review an Atompowered hybrid with great battery life

The Latitude 10's 10.1-inch screen sports a 1,366 x 768 resolution, which is par for the course when it comes to Atom-based tablets. More impressive than the pixel count is the 450-nit brightness rating; images really pop on this panel. When we watched Netflix, played a few games and surfed the web, all content appeared crisp, and colors looked accurate. Like the screens on the ASUS VivoTab Smart and the Lenovo ThinkPad Tablet 2, this display uses IPS technology, so you can expect wide viewing angles. We had no trouble making out a video from both the far left and right. Visibility would be even better if the display didn't have such a glossy finish, but that should only be an issue in settings with bright overhead lighting.

An active Wacom digitizer is available for about $34, and it's only compatible with the higher-end configurations of the Latitude 10. (The lower-end Essentials version will only work with a passive stylus.) We used the pen in programs such as Windows Journal, which includes handwriting recognition, and Paint. The stylus itself feels cheaply made; it doesn't provide as good of a grip as Samsung's S Pen, for instance. Still, it works well for selecting small objects on screen, and the capacitive display offers very good palm rejection. Only once or twice did the panel detect accidental input when we were writing with the digitizer. The Latitude 10 itself doesn't have a built-in slot for storing Wacom's device, but the soft-touch case that came with our review unit sports a penholder.

Audio doesn't get very loud on the Latitude 10. The two small stereo speakers are located on the back of the device, which means music and dialogue come through muffled when the tablet is on your desk (or your lap). Songs streamed via the Slacker app don't pack much punch at all, though -- as we always say with slates -- donning a pair of headphones allows for louder, slightly richer sound.

Performance and battery life


PCMark7 3DMark06 ATTO (top disk speeds)
Dell Latitude 10 (1.8GHz Intel Atom Z2760, Intel HD) 1,437 458 82 MB/s (reads); 35 MB/s (writes)
ASUS VivoTab Smart (1.8GHz Intel Atom Z2760, Intel HD) 1,400 372 83 MB/s (reads); 35 MB/s (writes)
Lenovo ThinkPad Tablet 2 (1.8GHz Intel Atom Z2760, Intel HD) 1,423 460 83 MB/s (reads); 35 MB/s (writes)
HP Envy x2 (1.8GHz Intel Atom Z2760, Intel HD) 1,425 N/A 83 MB/s (reads); 34 MB/s (writes)
Samsung ATIV Smart PC (1.8GHz Intel Atom Z2760, Intel HD) N/A 374 82 MB/s (reads); 36 MB/s (writes)
Acer Iconia W510 (1.8GHz Intel Atom Z2760, Intel HD) 1,297 N/A 81 MB/s (reads); 28 MB/s (writes)

As we mentioned in our review of the ASUS VivoTab Smart, lower-powered Windows tablets are pretty much uniform when it comes to specs. Like that product and literally every other competing model we've tested, the Latitude 10 runs an Intel Atom Z2760 processor clocked at 1.8GHz, with 2GB of RAM and the Intel Graphics Media Accelerator. It's no surprise, then, that Dell's slate turns in virtually identical benchmark scores to its competitors. In ATTO, the Latitude 10 notched max read and write speeds of 82 MB/s and 35 MB/s, respectively, and a cold boot takes about 15 seconds.

Unsurprisingly for an Atom-powered device, the Latitude 10 wasn't able to run the 3DMark 11 graphics benchmark, which requires DirectX 11 support. That's a good indicator of what kind of gaming performance to expect -- you'll be fine playing Angry Birds, Solitaire and the like, but serious titles are out of the question. We experienced a few glitches, such as app crashes and force quits throughout our hands-on time with the Latitude 10, but these moments were few and far between. Switching between apps didn't cause the system to stutter, and we never found ourselves tapping our fingers waiting for programs to load.

When we ran our battery test, which involves running a locally stored video on loop with WiFi on and brightness set to 65 percent, the Latitude's 30Wh battery lasted nine hours and three minutes. That compares favorably to other Atom-powered machines, such as the Acer Iconia W510 (8 hours and 19 minutes) and the HP Envy x2 (7 hours and 53 minutes). While that's fairly average for an Atom-powered Windows 8 tablet, it trumps them all when you add in the optional 60Wh power pack: with that attached, we got a jaw-dropping 16 hours of runtime.

Windows 8 systems Battery life
Dell Latitude 10 9:03 / 16:01 (extended battery)
ASUS VivoTab Smart 7:30
ThinkPad Tablet 2 10:27
Acer Iconia W510 8:19 (tablet only) / 14:17 (with the dock)
HP Envy x2 7:53 (tablet only) / 12:30 (with the dock)
Acer Iconia W700 7:13
Samsung ATIV Smart PC (AT&T) 7:04 (WiFi only) / 6:43 (LTE)

Camera

DNP Dell Latitude 10 review an Atompowered hybrid with great battery life

The Latitude 10 sports a 2-megapixel, 720p, front-facing camera for video chats along with a 8MP rear shooter with flash. When we took a few selfies in our brightly lit office, our images appeared grainy with a strong yellowish overcast. This is sadly the status quo for most tablet webcams, but moving to an area with natural light should help if you have to take a Skype meeting in a pinch.

Dell Latitude 10 sample shots

Our samples from the 8MP rear camera show fairly accurate colors and for the most part look quite sharp. Some pictures taken in shadowy settings look darker than they should, and images taken with flash unsurprisingly look very washed out. Camera options are fairly limited: there are controls for brightness and contrast, along with a toggle for auto or manual exposure. Sample video footage of Union Square in New York looked crisp and didn't exhibit much jerkiness. In short: if you insist on bringing a tablet along to document your adventures, the Latitude 10's cameras will certainly suffice.

Software and warranty


Dell bolsters the Latitude 10's cred as a business device with several security-minded features, including TPM and support for Computrace. Keep in mind that this software isn't available on the Essentials version of the device. The company also offers data encryption for protecting files.

We've seen more offensive pre-loads than the software selection on the Latitude 10. Out of the box, the tablet includes Dell Backup and Recover, a trial of Microsoft Office and Skype. You'll also find the standard Windows 8 apps, such as Bing, Maps and Weather. Our 3G-equipped configuration of the Latitude 10 also comes with the AT&T AllAccess utility for managing your data plan. Dell offers a standard one-year limited hardware warranty.

Configuration options and the competition


There are several available configurations of the Latitude 10, all with the same 1.8GHz Intel Z2760 processor and 2GB of RAM. On the lower end is the $499 so-called Essentials configuration, which runs Windows 8 and offers a 32GB SSD. For $80 more ($579 total), you can step up to a 64GB Essentials model. Next up the rung is the $649 Latitude 10, which gets you Windows 8 Pro, a 64GB SSD, a swappable battery, active stylus support and security features such as TPM. A $779, 64GB model includes those same features and adds a smart card reader and fingerprint reader, and it also supports mobile broadband. You could also spring for Dell's $849 Mobility bundle, which includes the productivity dock and 3G connectivity.
Some of the most useful features don't feel tailor-made for a portable lifestyle, and how useful are peripherals if they can't travel anywhere with you?

We took a look at two configurations of the Latitude 10. First up was the Mobility bundle, which Dell supplemented with several add-ons. With the four-cell swappable battery, Bluetooth keyboard and mouse, soft-touch case and Wacom digitizer, that option comes out to $1,019. (Note that Dell often runs promotions, so you may see slightly different prices.) Due to a faulty battery, though, Dell sent us another model to test: the Enhanced Security version with a fingerprint reader, smart card reader, swappable four-cell battery and the productivity dock. That configuration -- without peripherals such as the Bluetooth keyboard and mouse -- costs about $934. If you're going to go for the Latitude 10, we'd recommend shelling out for the full trappings, since you'll need a keyboard -- and likely an external monitor -- to get real work done. That said, those extras bring the price into Ultrabook territory, and you won't be getting Core i5-level performance with Dell's hybrid machine.

As always, we recommend surveying the field before committing to a product, and you have quite a few other options if the Latitude 10 piques your interest. When it comes to a good value, it's hard to beat the ASUS VivoTab Smart, which gets you 64GB of storage for $499. We like the 1.28-pound tablet's design -- with a polycarbonate back shell -- and relatively high-performing camera, but battery life isn't best in class, and there's no pen support. Acer's $550 Iconia W510 is another relatively inexpensive offering, and it has good battery performance and an IPS display in its favor. The downside is a cramped and unattractive keyboard dock -- and that brings the price up to $750.

If you want to wield a stylus, check out the Lenovo ThinkPad Tablet 2. This may just be our favorite low-powered Windows 8 hybrid, thanks to a comfortable keyboard and impressive longevity. Pen input does come at a slight premium, though: it's $649 for a 64GB, stylus-equipped model. Lenovo also has the more consumer-friendly IdeaTab Lynx (review coming soon). There's also the Samsung ATIV Smart PC Pro, which runs a full-fledged Core i5 CPU and includes an S Pen, but that will set you back $1,200.

Wrap-up

DNP Dell Latitude 10 review an Atompowered hybrid with great battery life

There are plenty of things to like about the Dell Latitude 10, in no small part due to the vast number of optional accessories that boost the device's productivity chops. Even without the swappable four-cell battery, this machine offers good longevity, and its bright IPS display stands out among other panels in its class.

That's not to say this product is without its flaws, though; some of the most useful features, such as the productivity dock and the optional keyboard, don't feel tailor-made for a portable lifestyle, and how useful are peripherals if they can't travel anywhere with you? The price is also pretty steep when you factor in all the extras that make this system so corporate-friendly. If your pockets can handle it, splashing out for the highest-end configuration with all the bells and whistles will net you a solid product. Those who need to stay south of $1,000, though, should consider the ThinkPad Tablet 2 and ASUS VivoTab Smart instead.

Update: The Dell Latitude 10 runs Intel's Graphics Media Accelerator, not Intel HD Graphics 4000.

Source: http://www.engadget.com/2013/03/22/dell-latitude-10-review/

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